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+Methylation of p53 protein by KMT7/SET7 is the first reported KMT-mediated methylation occasion on a non-histone protein 18 Since that discovery, a number of KMTs, in addition to KDM1A, have been recognized as p53 regulators that methylate or demethylate p53 protein, making p53 the most extensively studied non-histone protein undergoing lysine methylation 4 , thirteen , sixteen , 18 , 162 Here we use p53 as a model to debate the features of lysine methylation of non-histone proteins.
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