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In contrast with mouse thymocytes, mouse ES cells include higher ranges of total genomic H3K4me3 and have higher H3K4me3 occupancy on the promoter of the pluripotent gene Oct4 forty six In settlement with this, global decreases in H3K4me3 levels occur throughout retinoic acid (RA)-induced differentiation of mouse ES cells forty seven As well as, there are dynamic changes in H3K4me3 profiles at specific units of genes during ES cell differentiation.
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